Vaccination Eligibility

Based on eligibility guidance from DHS, vaccination is now recommended for:

  • Known contacts who are identified by public health via case investigation, contact tracing, and risk exposure assessments
  • People who know that a sexual partner in the past 14 days was diagnosed with mpox.
  • People who attended or had sex at a commercial sex venue or an event or venue where there was known mpox transmission or exposure.
  • Gay men, bisexual men, trans men and women, any men who have sex with men, and gender non-conforming/non-binary individuals, who:
    • Have had multiple or anonymous sexual partners in the last 14 days OR
    • Expect to have multiple or anonymous sex partners OR
    • Have new diagnosis of one or more nationally reportable sexually transmitted diseases (for example, acute HIV, chancroid, chlamydia, gonorrhea, or syphilis)
  • Sexual partners of people with the above risks 
  • People who anticipate experiencing the above risks
  • Clinical and research lab staff who directly handle orthopoxviruses or material that may contain orthopoxviruses
  • Healthcare providers who directly care for patients with sexually transmitted infections

Booking an Appointment

With Public Health Madison & Dane County

If you believe you are eligible for a vaccine, book a vaccination appointment now using the buttons below. 

  • If you had a known contact with someone that had mpox, or you are eligible for vaccine and are living with HIV, please call (608) 266-4821 so we can schedule you sooner.
  • If you've had a known or possible exposure, your appointment date should be within 14 days of the exposure. For example, if you had sex with someone with mpox on November 30, your appointment date should be December 14 or earlier.
  • You can use the links below to schedule a first and/or second dose. New appointments become available throughout the day, so check back often.


With Other Vaccinators

  • ​​​​​If you are a UW Health patient, and need another option for getting a mpox vaccine, you can call (608) 720-3355 to connect with UW Health scheduling staff.
  • If you are a UW-Madison student and need another option for getting a mpox vaccine, you can make an appointment at UHS.​​​​​

Vaccination Type

  • Providers across the country are now using an intradermal injection method

    • What's an intradermal injection? In simple terms, the injection will happen just below the surface of the skin, creating a small bump. An intradermal injection is similar to a TB test, if you’ve had one of those in the past. Watch this video to see what this type of injection looks like (Warning: Video contains imagery of a needle and medical procedure of vaccination). ​​​​​​
    • Why use this method? By switching to this intradermal method, our national supply of vaccine is now 4-5x greater than it was before. This means we can vaccinate more people even faster.
    • Is it effective? Current data tell us this type of vaccination method works just as well as a shot that goes into your muscle (also known as a subcutaneous shot).

  • Even if you received a shot in your upper arm for your first dose, it's fine to get an intradermal injection for your second dose. 

Vaccination Basics

  • There are two vaccines approved for mpox, JYNNEOS and ACAM2000. JYNNEOS is the preferred vaccine for nearly everyone. You can read more about the differences in the vaccines on the CDC website.

    • JYNNEOS contains a live virus that does not replicate efficiently in human cells.

    • The JYNNEOS vaccine is a two-dose series given at least 28 days apart. People are fully vaccinated about 2 weeks after their second shot of JYNNEOS.
    • Even once vaccinated, people should protect themselves from infection by avoiding close, skin-to-skin contact, including intimate contact, with someone who has mpox.
  • For considerations on getting a mpox vaccination with a COVID-19 vaccine, see the section on the CDC website titled, Coadministration of COVID-19 vaccines with other vaccines